Phthalocyanine-loaded nanostructured lipid carriers functionalized with folic acid for photodynamic therapy

Folic acid conjugated ferritins as photosensitizer carriers for photodynamic therapy.

We coupled folic acid as a tumour targeting ligand to the surface of ferritins and loaded them with ZnF16Pc. The resulting nanoconjugates can efficiently hone in on 4T1 tumours in vivo, and, with photoirradiation, leading to suppressed tumour growth and tumour metastasis.

Nanostructured lipid carriers loaded with resveratrol modulate human dendritic cells

Dendritic cells (DCs) are promising targets for drug delivery, as they can induce immunity or tolerance. The current study aims to examine the potential of using nanostructured lipid carriers (NLC) as delivery systems for human DC by evaluating nanoparticle internalization, cell labeling, and drug activity. NLC were formulated incorporating the fluorochrome fluorescein isothiocyanate (FITC-NLC)...

Itraconazol-Loaded Nanostructured Lipid Carriers (NLC) for Pulmonary Application

Folic Acid-conjugated Graphene Oxide loaded with Photosensitizers for Targeting Photodynamic Therapy

Photodynamic therapy (PDT) has emerged as an alternative and promising noninvasive treatment for cancer as well as non-cancer diseases, which involves the uptake of photosensitizers (PSs) by cancer cells followed by irradiation. The use of nanomaterials as carriers of PSs is a very promising approach to improve the development of PDT in clinical medicine. In this study, a novel folic acid-conju...

Nanostructured Carriers for Photodynamic Therapy Applications in microbiology

The antimicrobial activity of Photodynamic Therapy (PDT) was first described in the beginning of the last century. In an unintentional experiment, an accidental contamination of a paramecium culture with acridine orange solution and subsequent light exposure, induced the death of this microbe culture. After that, subsequent experiments showed that some dyes, such as acridine orange, phenotiazin...